Course Description

Advanced Cell Biology (3 CHs)

The course will focus on the molecular basis of cell structure/function and communication, with an emphasis on signal transduction pathways integrating cellular physiological at a more advanced level than in the introductory courses of Cell Biology. This course introduces advanced topics on the growth and division of eukaryotic cells and their differentiation through the review of selected examples of original research conducted in model organisms (yeast, Drosophila, Xenopus, plants, mammalians, cultured cells). This is a compulsory Module for MSc in Genetics and molecular diagnosis.

Advanced Biochemistry (3 CHs)

A comprehensive study of bio-energetic principles, the pathways, enzymes, and organic chemical mechanisms involved in the metabolic pathways of carbohydrates, lipids, amino acids, nucleic acids. Additional emphasis is on biochemical principles that are used in diagnostics of biomolecules. This is a compulsory Module for MSc in Genetics and molecular diagnosis.

Laboratory Applications in Molecular Diagnostic (3 CHs)

Students will study molecular techniques that are used in diagnostics with emphasis on nucleic acid based techniques including methods based on amplification, sequencing, hybridization or combinations in addition to quality assurance in the molecular laboratories. Students will also be trained in principles and analyzing diagnostic methods that are commercially available. This is a compulsory Module for MSc in Genetics and molecular diagnosis.

Advanced Bioinformatics ( 3 CHs)

The course aims to provide large scale analyses of DNA, RNA and protein sequences by programming and scripting based on command-line tools and using Linux operating system.  The course will cover the following .topics based on command line tools: access to information, pairwise alignment BLAST, databases searching, multiple alignment phylogeny, chromosomes, next generation sequencing, RNA sequences, protein structure, functional genomics human genome and human diseases. This is a compulsory Module for MSc in Genetics and molecular diagnosis.

Microbial Genetics and Genomics (2 CHs)

In this module the student will learn about the genomic structure of microorganism and provides a brief introduction on genomics concepts and approaches, emergence of the genomic era. Methods of genome sequencing and annotation, transcriptomic approaches, proteomics approaches. Advances made by genomics studies on the understanding of microbial genome organization, evolution and functioning are then discussed. Emphasis of the human microbiota and its importance. Infection in context as a cause of national and global morbidity and mortality. Methods of diagnostics, susceptibility testing and strain typing in clinical microbiology with special reference to the place of genomic methods and their advantages and disadvantages in clinical diagnostics. This is a compulsory Module for MSc in Genetics and molecular diagnosis.

Quantitative Research and Biostatistics (2 CHs)

This course is designed to provide students with the skills necessary to conduct research, to consider questions being asked, to select appropriate measurement tools and types of data to be collected, sampling methods and data management and the course also focuses on applied statistics utilizing computer analysis of data with a revision of essential statistical tests, selection of appropriate statistical
tests and output interpretation. This is a compulsory Module for MSc in Genetics and molecular diagnosis.

Forensic Molecular Biology (2 CHs)

Forensic molecular biology emphasizes molecular techniques such as DNA profiling and repetitive DNA in the genome.  Additionally, students will get exposure to Analyze biological evidence from humans and other organisms.  New developments in the field of forensic DNA analysis will also be examined. This is an elective Module for MSc in Genetics and molecular diagnosis.

Molecular Immunology (2 CHs)

This course is an extension of the Basic Immunology, providing the tools to interpret the molecular mechanisms of the natural and adaptive immune response and of the pathogenesis of diseases in which the immune system is involved. Furthermore, this course insight into the origin of immune pathological processes, therapeutically strategies for their treatment and the basic immunological techniques. This is an elective Module for MSc in Genetics and molecular diagnosis.

Genetics of Human Diseases (2 CHs)

The course aims to make the genetic effect of human diseases understood. The course covers the gap between genotype and phenotype by revealing the effect of a variant on gene and then its effect on a person. It also covers the identification of genes and variants for monogenic disorders and the identification of susceptible factors for complex diseases including cancer. Moreover, the various genetic tests including tests for specific genetic variants, clinical diagnostic testing and  population screening beside the genetic approach to treat disease's will be covered. This is an elective Module for MSc in Genetics and molecular diagnosis.

Molecular Parasitology (2 CHs)

This course will explore the molecular biology and mechanisms of virulence of eukaryotic protozoan parasites that are major causes of human disease and misery in most countries of the tropics. The entry of molecular biology with its elucidation of the genetics, genomics and proteomics of these organisms has provided increasingly sophisticated explanations of their capacities to persist under intense ecological and physiological pressures. The students: (i) will gain a detailed understanding of the molecular biology of these organisms; (ii) will increase their ability to read scientific papers and (iii) will be able to analyze and discuss some of the molecular laboratory techniques presented during the course. This is an elective Module for MSc in Genetics and molecular diagnosis.

Molecular Virology and Mycology (2 CHs)

This module will focus on the general concepts in medical and molecular virology and mycology. These will include the varied structure and replication mechanisms of viruses and fungi along with pathogenesis, epidemiology, immunity, and
nucleic acid diagnosis of systemic, subcutaneous and superficial of viral mycolic infections.

This is an elective Module for MSc in Genetics and molecular diagnosis.

Molecular Environmental Techniques (2 CHs)

This course will provide students with knowledge from the interphase
between environmental and molecular biology with a specific focus on
the use of modern molecular methods in environmental biology. The
course focusses on how environmental and anthropogenic stressors (e.g.,
drought, heat, chemicals) affect organisms at the physiological and
molecular levels and on the molecular tools that can be applied in order
to conduct such assessments. Students will learn how to identify and
quantify selected stress responses (e.g. photosynthetic and respiratory
rate, oxidative stress, DNA-damage, gene expression of stress proteins)
and genetic changes in populations. This is an elective Module for MSc in Genetics and molecular diagnosis.

Statistical Genetics (2 CHs)

This course will teach the students the methods of statistical analysis for molecular genetics data. The course will cover the following topics: detecting errors in the generated genetic data, family’s studies, populations studies, linkage analysis in terms of model based and model free, family based association analysis and genome wide association studies. This is an elective Module for MSc in Genetics and molecular diagnosis.

Advanced Hematology (2 CHs)

This course provides a comprehensive study of the physiology and regulation of the hematopoietic system, and the genetic, molecular and cellular mechanisms underlying the pathophysiology of selected anemias, leukemia and lymphomas. Utilization of appropriate laboratory tests for screening, molecular diagnosis, monitoring, and determining prognosis are discussed and applied through clinical scenarios and case studies. Review of current scientific literature and advanced laboratory practice issues are also covered. This is an elective Module for MSc in Genetics and molecular diagnosis.

Plant genetics and Genomics (2 CHs)

This module will provide an in-depth study of the applications of plant molecular genetics, genomics and transformation technologies in both model and crop plants. This is an elective Module for MSc in Genetics and molecular diagnosis.